insulin receptor

基本解釋

In order for a cell to respond directly to insulin it must display an insulin receptor on its surface.
為了使一個(gè)細(xì)胞能夠直接對(duì)胰島素做出反應(yīng)，因此在它表面必須有一個(gè)胰島素受體。
To confirm this, the researchers gave the insulin receptor-deficient mice osteocalcin, which improved their metabolic abnormalities.
為了驗(yàn)證這一說(shuō)法，研究者們給這些缺少胰島素受體的實(shí)驗(yàn)小鼠們注入了骨鈣蛋白，而這一舉動(dòng)確實(shí)改善了它們的代謝反常現(xiàn)象。
International Diabetes: Doctor do you think that the modulation of Insulin receptor signaling is the major method to improvement insulin resistance?
國(guó)際糖尿病：教授，您認(rèn)為調(diào)節(jié)胰島素受體信號(hào)是改善胰島素抵抗的主要方法嗎？
www.idiabetes.com.cn

It gets enhanced because when insulin binds to the insulin receptor, it activates the receptor.
這種增強(qiáng)效應(yīng)來(lái)自于,胰島素與胰島素受體結(jié)合后,就激活了該受體
耶魯公開課 - 生物醫(yī)學(xué)工程探索課程節(jié)選
Insulin, the ligand binds to its receptor, creates a change through a kinase activity that's exposed, which leads to other biochemical changes, which leads to a change in cell behavior - in this case the cell behavior is that more glucose transporters are brought to the membrane and more glucose can enter the cell.
胰島素,一種能夠與受體結(jié)合的配體,通過其暴露出的激酶活性引起的變化,導(dǎo)致了其它后續(xù)生化變化的發(fā)生,進(jìn)而使細(xì)胞行為發(fā)生改變,這個(gè)例子中的細(xì)胞行為就是,更多的糖載體被帶到細(xì)胞膜表面,這樣更多的糖分子進(jìn)入到細(xì)胞內(nèi)部
耶魯公開課 - 生物醫(yī)學(xué)工程探索課程節(jié)選

Sometimes it is a normal gene that directs the production of a hormone, such as insulin, or of the cell machinery which that hormone stimulates, such as the insulin receptor.
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We will routinely turn off genes that promote disease and aging such as the fat insulin receptor gene that tells the fat cells to hold onto excess fat.
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